keap1 nrf2 in 1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11752	Keap1-Nrf2-IN-1	Keap1–Nrf2-IN-1	Src
	Keap1–Nrf2 IN-1 activates Nrf2-regulated cytoprotective response and antagonizes acetaminophen-induced liver injury both in cellular and in vivo models. Keap1–Nrf2 IN-1 is a Kelch-like ECH-associated protein 1-nuclear fa...		Src
T12253	Nrf2-IN-1		Others , Nrf2
	Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).		Others , Nrf2
T39514	Keap1-Nrf2-IN-3	Keap1-Nrf2-IN-3
	Keap1-Nrf2-IN-3 is a KEAP1:NRF2 protein protein interaction inhibitor, and with a K d value of 2.5 nM for KEAP1 protein.
T64218	Keap1-Nrf2-IN-1 TFA
	Keap1-Nrf2-IN-1 TFA (compound35) is a Keap1-Nrf2 protein-protein interaction inhibitor (IC50: 43 nM) that activates Nrf2-regulated cytoprotective responses. Keap1-Nrf2-IN-1 TFA antagonizes acetaminophen-induced liver inj...
TN5171	Tricetin		Apoptosis , Others , Nrf2
	Tricetin is a flavonoid isolated from pomegranate.Tricetin is a potent competitive inhibitor of Keap1-Nrf2 protein-protein interaction (PPI) and protects Parkinson's disease patients from 6-OHDA-induced neurotoxicity by ...		Apoptosis , Others , Nrf2
T6S0525	Farrerol		ERK , p38 MAPK , Akt
	1. Farrerol has antioxidative activity.2. Farrerol modulates TAP and BNBD5 gene expression in mammary gland, enhances bMEC defense against S. aureus infection and could be useful in protection against bovine mastitis. 3....		ERK , p38 MAPK , Akt
T74600	Keap1-Nrf2-IN-9
	Keap1-Nrf2-IN-9 (compound 11) is a potent inhibitor of the Keap1-Nrf2 protein−protein interaction (PPI) with an IC50 value of 0.575 µM. It enhances the expression of Nrf2 target genes, including heme oxygenase 1 (Hmox1),...
T78841	Nrf2-IN-3
	Nrf2-IN-3 (Compound R16), a Nrf2 inhibitor, binds to KEAP1 mutants (G333C mKEAP1) thereby restoring the impaired KEAP1/NRF2 interactions. This restoration sensitizes KEAP1-mutant cancer cells to chemotherapeutic agents, ...
T78697	Keap1-Nrf2-IN-15
	Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, displaying IC50 values of 77 nM in a fluorescence polarization (FP) assay and 2.5 nM in a time-resolved fluorescence re...
T72687	Keap1-Nrf2-IN-11
	Keap1-Nrf2-IN-11 (Compound 6k), a potent Keap1-Nrf2 inhibitor, exhibits a dissociation constant (KD) of 0.21 nM. It hampers the production of reactive oxygen species (ROS) and nitric oxide (NO), as well as the expression...
T79698	S217879
	S217879 is a potent and selective activator of NRF2 that disrupts the KEAP1-NRF2 interaction, resulting in significant activation of the NRF2 pathway. This compound is applicable in research on non-alcoholic steatohepati...
T81984	Keap1-Nrf2-IN-10
	Keap1-Nrf2-IN-10 (compound 15) is a potent inducer of NQO1 and efficaciously mitigates oxidative stress in gamma-irradiated mice by reducing MDA and ROS levels, as well as NQO1 in the liver, which enhances the survival r...
T61688	Nrf2 activator-2
	Nrf2 activator-2 (referred to as compound O15), an Osthole derivative, is a highly potent Nrf2 agonist exhibiting an EC 50 of 2.9 μM in 293 T cells. By effectively disrupting the binding between Keap1 and Nrf2, Nrf2 acti...
TP2109	TAT 14		Nrf2
	Nrf2 activator; inhibits Nrf2/Keap1 interaction. Induces upregulation of Nrf2 pathway downstream gene expression including heme-oxygenase 1. Suppresses LPS-induced TNF-α expression in THP-1 cells.		Nrf2
T61773	Keap1-Nrf2-IN-4
	Keap1-Nrf2-IN-4, a powerful neddylation inhibitor, demonstrates significant anti-proliferation activity against MGC-803 cells (IC50 = 2.55 μM), effectively impeding their migration and inducing apoptosis. Additionally, i...
T75485	Dehydrobruceine B
	Dehydrobruceine B, a quassinoid isolated from Brucea javanica, demonstrates a synergistic effect with Cisplatin in inducing apoptosis through the mitochondrial pathway. It enhances the expression of apoptosis-inducing fa...
T64214	NXPZ-2
	NXPZ-2 is an orally active Keap1-Nrf2protein-protein interaction (PPI) inhibitor (Ki: 95 nM, EC50: 120 and 170 nM). NXPZ-2 dose-dependently attenuates Aβ[1-42]-induced cognitive disturbances, enhances neuronal number and...
TN3806	Dehydroglyasperin C		ERK , IκB/IKK , p38 MAPK , TNF , NF-κB , Akt , COX , PI3K , NADPH , DNA/RNA Synthesis , Nrf2 , JNK , Autophagy
	Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemopreventive, and neuroprotective activities, it has protectiv...